Neuropeptide Deep Crease Serum

This targeted serum is engineered around a potent neuropeptide complex - bioactive molecules that interact with neuromuscular signaling pathways in the skin, helping to visibly soften the appearance of deep, expression-related lines and creases over time. By modulating the repetitive muscle micro-contractions that etch lines into the skin's surface, neuropeptides address one of the primary mechanical drivers of facial aging - without needles, without downtime.

The formula is further anchored by Perricone MD's phospholipid delivery system, which enhances penetration of actives into the dermal layer while simultaneously reinforcing the skin's lipid barrier. The result is a visibly smoother, more plumped surface where deep creases - particularly around the forehead, brow, and nasolabial area - appear measurably reduced with consistent use. Precise, concentrated, and built for those who want clinical-level results from their daily skincare routine.

Targeted Deep Crease Reduction - Neuropeptides interact with neuromuscular pathways to help soften the appearance of expression lines, addressing one of the primary mechanical causes of deep facial creasing.
Clinically Concentrated Formula - Formulated as a serum concentrate rather than a general moisturizer, delivering a higher active payload directly to crease-prone areas where standard formulas rarely penetrate effectively.
Phospholipid Delivery Enhancement - The phospholipid base mimics the skin's own lipid structure, enabling deeper delivery of actives into the dermis while simultaneously repairing the skin's barrier function.
Visible Plumping of Crease Depth - By improving hydration retention within the dermal layers and supporting structural proteins, the skin surface appears measurably more plump and smooth along crease lines over time.
Barrier Reinforcement - Phospholipids reduce transepidermal water loss (TEWL), keeping crease-prone skin supple and preventing the dehydration that makes lines appear more exaggerated.
Non-Invasive Expression Line Management - Provides a daily-use topical alternative to injectable treatments for those seeking to visibly reduce deep lines through consistent skincare rather than cosmetic procedures.
Cumulative, Long-Term Results - Neuropeptide activity builds measurably over weeks of consistent use, making this a long-term investment in structural skin health rather than a temporary cosmetic fix.

Targeted Application Protocol - Morning & Evening:

Apply to clean, dry skin after cleansing and any toner or essence, before moisturizer and SPF.
Precision Application Method:

Dispense 1–2 pumps onto fingertips. Apply directly to areas of deep creasing - forehead lines, frown lines between brows (glabellar lines), nasolabial folds, and lip lines. Use the ring finger (lightest pressure finger) to gently press and smooth the serum along each crease line rather than rubbing across it. This pressing motion encourages better penetration along the crease where the product is needed most.
Timing & Layering:

Morning: Follow immediately with a hydrating moisturizer and broad-spectrum SPF 30+ - UV exposure accelerates collagen degradation and counteracts neuropeptide benefits.
Evening: Layer under a richer night cream or face oil to extend the serum's activity during the skin's peak overnight repair window (approximately 11 PM-4 AM).
Allow 45-60 seconds for the serum to absorb before layering additional products.

Synergy Tips:

For maximum crease reduction, use in combination with the Neuropeptide Firming Facial Concentrate - apply the Concentrate to the full face first, then layer this serum directly onto crease zones for a targeted double-peptide approach.
Consistent daily use for a minimum of 8–12 weeks yields the most meaningful cumulative improvement - neuropeptide results build progressively rather than delivering overnight change.
Avoid applying directly on top of active retinol on the same layer - alternate evenings or allow retinol to absorb fully before applying.

-Water/Aqua/Eau, Niacinamide, Coconut Alkanes, Glycerin, Caprylic/Capric Triglyceride, Isodecyl Neopentanoate, Squalane, Isononyl Isononanoate, Butylene Glycol, Lactobacillus/Glycine Soybean Ferment Extract, Polyglutamic Acid, Phenoxyethanol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Chlorella Vulgaris Extract, Glyceryl Stearate Citrate, Coco-Caprylate/Caprate, Hydroxyacetophenone, Polyglyceryl-3 Stearate, Hydrolyzed Rice Protein, Sodium Hyaluronate, Propanediol, Xanthan Gum, Pullulan, Hydrogenated Lecithin, Fragrance (Parfum), Polysorbate 60, Citric Acid, Sodium Phytate, Malus Domestica Fruit Cell Culture Extract, Sorbitan Isostearate, Glyceryl Stearate, Pentylene Glycol, Carbomer, Ceteareth-25, Coco-Glucoside, Sodium Lactate, Ubiquinone, Lecithin, Sodium Benzoate, Potassium Sorbate, Caprylyl Glycol, Acetyl Hexapeptide-8, Ceteareth-6, Lactic Acid, Pterocarpus Marsupium Bark Extract, Tocopherol, Stearyl Alcohol, Acetic Acid, Ethylhexylglycerin, Palmitoyl Tripeptide-1, Sodium Hydroxide, Palmitoyl Tetrapeptide-7, Nicotiana Benthamiana Hexapeptide-40 SH-Oligopeptide-1, Nicotiana Benthamiana Octapeptide-30 SH-Oligopeptide-2, Citronellol, Hydroxycitronellal, Limonene, Linalool

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The Skin Love Cream is shipped free on all US orders with the carriers USPS and UPS. Unfortunately we do not ship abroad. Please see our shipping information page for more information.

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Inquiries? Questions?

We are there for all your demands. Call us 646 481.4881  from Monday to Friday 9 am to 6 pm EST (except official holidays) or send us an email to hello@skinlovecream.com

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